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nanoScan® PET/CT

PET/MRI 1T and SPECT/CT/PET

Real dynamic PET-system designed for quantitative studies

The nanoScan® PET system is equipped with ultra-fast electronics, and the finest detector crystal pixels in thick layers, ensuring high spatial resolution (down to 700 μm in vivo), and quantitative results, delivered over the widest dynamic range of radioactivity levels from 60 Bq to 80 MBq (1.6 nCi – 2.16 mCi). Combining this with the large axial and transaxial FOV of the PET ring, imaging of large or multiple animals simultaneously is possible, even with 11C- and 15O-labelled radiotracers.

Large ring diameter allows imaging of multiple mice and large animals, while the unique, Tera-Tomo™ 3D iterative reconstruction based on real-time Monte Carlo simulation ensures homogeneous image quality over the entire field of view.
Open access to the animal during PET scanning gives full control over the animal studies.

The PET system is also available in triple-modality combination with our high-end SPECT (nanoScan SPECT/CT/PET) or fully integrated with MRI (nanoScan PET/MRI).

Features & Benefits

Resolving precise details with 700 μm spatial resolution

  • Finest (1.12mm×1.12mm) lutetium oxyorthosilicate (LSO) crystal needles provide precise signal localization preserving spatial information in raw data
  • Tera-Tomo™ 3D PET iterative reconstruction with real-time Monte Carlo based physical modelling unveiling the tiniest details on the image
  • Large ring diameter and statistical depth of interaction compensation offers homogeneous image quality over the entire field of view

Uncompromised applications with very low level of radioactivity

  • Thick LSO crystals for excellent sensitivity
  • Short (3 ns) coincidence time window necessary for improved signal to noise ratio
  • Advanced corrections (random, scatter, LSO background etc.) ensuring quantification at low activity levels
  • Best Minimal Detectable Activity on the market: 60 Bq (1.6 nCi)
  • Dedicated feature of the iterative Tera-Tomo™ 3D PET reconstruction engine ensures precise quantification at very low levels of activity 
  • Analytic reconstruction option (FBP) with attenuation and scatter correction available for quantitative reconstruction of low activities close to regions with significantly higher activity 
  • Inherently optimized for longitudinal studies e.g. long-term cell tracking.

Coping with count rate: mastering studies with high dose

  • Multichannel read-out electronics with ultra-fast data processing and advanced dead-time correction
  • Exceptional count rate performance – peak Noise Equivalent Count Rate (NECR) for mouse is up to 1300 kcps @ 80 MBq (2.16 mCi)
  • Accurate and reproducible uptake values ensured by very high level of quantification accuracy up to 80 MBq (2.16 mCi) and beyond, with quantification error of ±2%
  • Suitable for dynamic imaging of large animals or for dynamic scanning of up to four mice or two rats simultaneously
  • Optimal for imaging of isotopes with short half-life (11C, 13N, 15O, etc.)

Largest transaxial field of view

  • Wide bore diameter up to 16 cm allowing free access to the animals
  • Large transaxial field of view up to 12 cm
  • Excellent homogeneity over the entire field of view
  • Suitable for various animal models from tiny mouse (25 g) to large rabbits (6.5 kg)
  • Simultaneous multiple animal imaging (up to 4 mice or 2 rats) with individual physiological monitoring

Excellent image quality and quantitation accuracy with the Tera-Tomo™ image reconstruction

Our proprietary iterative reconstruction engine, used in both clinical and preclinical systems ensures quantitative results with excellent resolution for all PET isotopes. 

  • The Tera-Tomo™ 3D PET reconstruction engine along with the most advanced detector calibration algorithms ensure a very high level of quantification accuracy through the entire dynamic range of the system. The quantification error of +/- 2% results in accurate and reproducible uptake values 
  • 3D iterative reconstruction applying deep Monte Carlo based physical modelling of particle-level interaction from positron emission to detection
  • Advanced corrections for energy, time, dead-time and random events and positron range
  • CT or MR based attenuation and scatter correction
  • Automated workflow with 4D multiparametric PET reconstruction for fast kinetic analysis of dynamic acquisitions

High power CT with large field-of-view and high resolution

  • Up to 80 W X-ray power together with the largest field of views (12 cm transaxial and 45 cm helical scan range) enables high performance scanning of even large or multiple animals
  • Very high throughput: fast scanning with real-time image reconstruction combined with multiple animal imaging capability
  • Variable magnification (up to x7.6) for high-resolution imaging even with 10 μm isotropic voxel size
  • Iterative image reconstruction for low-noise and low-dose imaging
  • Ultra-low-dose protocol for follow-up studies with less than 1 mGy whole-body dose to the animal for reliable longitudinal studies, e.g. following tumour growth or therapy response
  • Imaging with cardiac and respiratory gating for reducing motion artifacts and for analysis of cardiac and pulmonary function.

Applications

Images

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