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nanoScan® SPECT/CT/PET

nanoScan® SPECT/CT/PET

Versatile SPECT with Real dynamic PET with absolute quantification

The nanoScan® triple modality system combines all benefits of the nanoScan® PET/CT and SPECT/CT in a single, fully integrated device.
The SPECT part images radiotracers with absolute quantification, high sensitivity and high spatial resolution down to 0.3 mm in vivo. Wide range of patented multi-pinhole collimators available with optimized performance for any applications: from whole-body to focused scanning; imaging of mice, multiple mice, large rats and rabbits; from low energy tracers to theranostic isotopes.
The PET part is equipped with the finest detector crystal needles ensuring high spatial resolution down to 700 μm in vivo. Quantitative results delivered over the widest range of radioactivity levels from 60 Bq to 80 MBq (1.6 nCi – 2.16 mCi). Large ring diameter allows imaging of multiple mice and large animals.
The triple modality system is also available as a combination of an integrated PET/CT and a standalone SPECT for higher throughput.

Features & Benefits

High sensitivity and high resolution SPECT simultaneously

  • Proprietary and patented multi-pinhole collimator technology offering excellent spatial resolution, high sensitivity and large field of view at the same time
  • Cutting-edge sensitivity even for high-energy isotopes ensured by 9.5 mm thick sodium iodide (NaI:Tl) crystals with large area and minimal detector gaps
  • Exclusive imaging performance with ultra-low activity

Wide range of collimators: for fast dynamic SPECT and for imaging of Theranostic isotopes

Full stationary imaging:

  • PET-like dynamic imaging capability with list mode data storage
  • 3D quantitative dynamic imaging with 1-3 second time frames
  • Time-Activity Curve generation from 3D quantitative results.

Imaging of high energy tracers:

  • Dedicated multi-pinhole collimators for Imaging of theranostic isotopes like 131I, 213Bi, 225Ac and more
  • List-mode data acquisition for simultaneous imaging of multiple isotopes, even for simultaneous scanning of PET and SPECT tracers.

Resolving precise details with PET: 700 μm spatial resolution

  • Finest (1.12mm×1.12mm)  lutetium oxyorthosilicate (LSO) crystal needles provide precise signal localization preserving spatial information in raw data
  • Tera-Tomo™ 3D PET iterative reconstruction with real-time Monte Carlo based physical modelling unveiling the tiniest details on the image
  • Large ring diameter and statistical depth of interaction compensation offer homogeneous image quality over the entire field of view

Coping with count rate: mastering studies from high dose to low dose

  • Multichannel read-out electronics with ultra-fast data processing and advanced dead-time correction
  • Exceptional count rate performance – peak Noise Equivalent Count Rate (NECR) for mouse is up to 1300 kcps @ 80 MBq (2.16 mCi)
  • Accurate and reproducible uptake values ensured by very high level of quantification accuracy up to 80 MBq (2.16 mCi) and beyond, with quantification error of ±2%
  • Suitable for dynamic imaging of large animals or for dynamic scanning of up to four mice simultaneously
  • Optimal for imaging of isotopes with short half-life (11C, 13N, 15O, etc.)
  • Thick LSO crystals and advanced corrections (random, scatter, LSO background etc.) ensuring quantification at low activity levels
  • Best Minimal Detectable Activity on the market: down to 60 Bq (1.6 nCi)

Largest Field of View for large or multiple animal imaging

  • Wide gantry opening: up to 27 cm in SPECT and up to 16 cm in PET
  • Various animal models from tiny mouse (25 g) to large rabbits (6.5 kg / 14.3 lb)
  • Multiple mouse imaging chamber with physiological monitoring feature for all animals
  • Wide range of collimation techniques and collimators: Single-Pinhole, Multi-Pinhole and Parallel-hole

Excellent image quality and quantification accuracy with the Tera-Tomo™ image reconstruction

Our proprietary iterative reconstruction engine, used in both clinical and preclinical systems ensures quantitative results with excellent resolution for all PET isotopes. 

  • The Tera-Tomo™ 3D PET reconstruction engine along with the most advanced detector calibration algorithms ensure a very high level of quantification accuracy through the entire dynamic range of the system. The quantification error of ±2% results in accurate and reproducible uptake values 
  • 3D iterative reconstruction based on real-time Monte Carlo simulation applying physical modelling of particle-level interaction from positron emission to detection
  • Advanced corrections for energy, time, dead time, random events and positron range
  • CT- or MR-based attenuation and scatter correction
  • Automated workflow with 4D multiparametric PET reconstruction for fast kinetic analysis of dynamic acquisitions.

High-power CT with large field of view and high resolution

  • Up to 80 W X-ray power together with the largest field of views (12 cm transaxial and 45 cm helical scan range) enables high performance scanning of even large or multiple animals 
  • Very high throughput: fast scanning with real-time image reconstruction combined with multiple animal imaging capability
  • Variable magnification (up to ×7.6) for high-resolution imaging even with 10 μm isotropic voxel size
  • Iterative image reconstruction for low-noise and low-dose imaging
  • Ultra-low-dose protocol for follow-up studies with less than 1 mGy whole-body dose to the animal for reliable longitudinal studies, e.g. following tumour growth or therapy response
  • Imaging with cardiac and respiratory gating for reducing motion artifacts and for analysis of cardiac and pulmonary function.

Applications

Images

Specification

PET
CT
SPECT
Gantry opening
up to 16 cm
Transaxial FOV
up to 12 cm
Axial FOV
up to 15 cm
Animal models
Mouse, rat, marmoset, guinea pig, rabbit
Multiple animals
up to 4×60 g mice                            2×300g rats
Detector crystal
LSO (1.12×1.12×13 mm)
Spatial Resolution with Tera-Tomo (3D OSEM)
down to 0.7 mm
Spatial Resolution with FBP (NEMA)
down to 1.25 mm
Sensitivity
up to 10.5% (250-750 keV)
Noise Equivalent Count Rate for mouse (NEMA)
up to 1300 kcps @ 80 MBq
Noise Equivalent Count Rate for rat (NEMA)
up to 250 kcps @ 60 MBq
X-ray power
up to 80W
Gantry opening
16 cm
Field of View
Transaxial: 12 cm; Axial: 10 cm
Animal models
mouse, rat, marmoset, guinea pig, rabbit
Image reconstruction
modified Feldkamp-type for Real-time recon; Iterative for low dose and low noise applications
Spatial resolution
30 μm at 10 μm voxel size
Low-dose protocol
down to 1 mGy for whole-body mouse
Detector crystal
9.5 mm NaI(Tl)
Bore size
up to 27 cm
Animal models
from tiny mouse to large, 6.5 kg rabbits, up to 3 mice simultaneously
Spatial resolution
down to 0.3 mm
Sensitivity
up to 13 000 cps/MBq
Energy range
from 125-I to Theranostic and PET isotopes
Collimators
Multi-pinhole – proprietary M3-pinhole™ technology; Single pinhole; Parallel hole
Dynamic imaging
Yes, ultra-fast 4D/5D list mode dynamic imaging by static or rotational SPECT
Acquisition schemes
SPECT (3D): helical, circular, semi-stationary and full stationary Planar (2D): static, dynamic

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