Exceptional spatial resolution for quantitative analysis of small structures

Precise quantification of tiny objects, like the substantia nigra in the brain or tuberculosis granulomas in the lungs, require high spatial resolution.

• MultiScan™ LFER 150 PET/CT can achieve better than 1 mm spatial resolution
• This translates to more than 75% recovery for the 2 mm rod in the NEMA image quality test
• Using precise detector modelling and attenuation and scatter correction in the Tera-Tomo™ 3D PET reconstruction the system achieves better than 5% homogeneity measured with a 15 cm diameter water filled phantom.

Outstanding quantitative accuracy in both time and activity range

Applications involving short half-life isotopes, like ¹¹C and ¹⁵O or long scan times, like cell tracking require good quantitative accuracy over a wide range of radioactivity levels.

• Due to its powerful read-out electronics and efficient dead-time compensation the MultiScan™ LFER150 PET/CT features a peak noise equivalent count rate (NECR) of 398 kcps @ 149 MBq for rat-like and 64.7 kcps @ 128 MBq for monkey-like phantoms (NEMA)
• Moreover, it enables better than 3% accuracy for up to 150 MBq in the field of view, independent from the size of the object
• Low activity imaging is ensured by high sensitivity of over 5%.

Fast CT with high resolution

The high, isotropic spatial resolution of the CT system is very suitable for characterizing and tracking tuberculosis granulomas.

• The cone-beam CT delivers better than 200 µm isotropic spatial resolution with 50 µm voxel size
• Full tomographic scans of less than 40 seconds allowing breath-hold CT imaging
• High resolution lung scans in smaller animals are supported by respiratory gating
• Noise performance and soft tissue contrast are improved by iterative CT reconstruction.

Proven operation in BSL-3 environment

There are 7 MultiScan™ LFER150 PET/CT running worldwide in laboratories operating under biosafety level 3 (BSL-3) conditions.

These systems perform up to 1000 scans per year and regularly endure sterilization.

Research is focusing on wide range of infectious diseases including vaccine development for COVID-19.

Animal handling

The compact and versatile gantry has two animal support modules:

• MobilCell animal bed:
  • Up to 60 cm imaging length
  • Fits up to 16 kg (35 lb) rhesus monkeys
  • Compatible with MultiCell imaging chambers for rodent, including heating and physiological monitoring
• Primate chair:
  • Awake non-human primate studies
  • Freely tilted gantry covers the brain while ensures free visibility for application of visual stimuli, like no system before.