Vanessa J Kelly et al., Theranostics, 2020
Triple-negative breast cancers (TNBC) are associated with poor prognosis and high mortality rates following relapse. These cells do not express estrogen, progesterone or HER2/neu receptors, which means that receptor targeted therapies can’t be utilized. These cells overexpress transformed MUC1 (tMUC1) antigen, which is selectively bound by murine antibody TAB004. Once TAB004 binds to tMUC1 it has been shown to internalize, which makes them excellent therapeutic candidate for TNBC.
Current study aimed to evaluate humanized TAB004 (hTAB004) as a potential theranostic for TNBC. hTAB004 was labeled either with Indium-111 (for biodistribution analysis) or Actinium-225 (for alpha radiotherapy) and injected intravenously to orthotopic tumor bearing mice. Results demonstrate both high tumor concentrations and high tumor-to-blood ratios. Additionally, a single administration of 225Ac-DOTA-hTAB004 increased survival and resulted in consistently lower tumor volumes compared to the control group after 12 days. Together they are convincing proof-of-concept support for hTAB004 as a theranostic agent in triple negative breast cancer.
Results from nanoScan SPECT/CT
In vivo biodistribution studies: NSG mice were inoculated with HCC70 tumors. 27 days later 7.5MBq 111In-DOTAhTAB004 was intravenously injected via the tail vein. SPECT-CT imaging was performed at 4, 24, 48 and 120 h postinjection.
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