Mudan Cai et al., Journal of Neuroinflammation, 2019
Current study investigated the electroacupuncture (EA)-induced molecular mechanisms causing cognitive improvement and anti-inflammatory activity in 5XFAD mice, a transgenic animal model of Alzheimer’s Disease (AD). Mice were bilaterally treated with EA three times per week for 2 weeks, thereafter Y-maze tests, western blots, immunohistochemistry, and PET scans were performed. Results revealed that EA treatment significantly improved working memory and synaptic plasticity, activated cell metabolism in the frontal cortex and the hypothalamus, concomitantly reduced neuroinflammation, ultrastructural degradation of synapses, and the microglia-mediated amyloid β deposition.
Results from nanoScan PET/CT
For the PET/CT studies, 7.4MBq 18F-FDG was intravenously injected via the tail vein to the following treatment groups: a) non-transgenic (non-Tg), b) 5XFAD (Tg) and c) EA-treated 5XFAD (Tg+KI3). After 60min uptake period, 30min long PET acquisitions were performed. Data were reconstructed with Tera-Tomo 3D reconstruction method. For quantitative analysis regions of interest were drawn into the frontal cortex, cortex, hippocampus, and hypothalamus and standardized uptake values (SUV) were evaluated to determine the effect of EA treatment on brain metabolism.
Result revealed that:
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