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nanoScan® PET/CT

PET/MRI 1T and SPECT/CT/PET

Real dynamic PET-system designed for quantitative studies

The nanoScan® PET system is equipped with the finest detector crystal needles ensuring high spatial resolution down to 700 μm in vivo.

Quantitative results delivered over the widest range of radioactivity levels from 60 Bq to 60 MBq (1.6 nCi – 1.6 mCi). It covers the full range of PET applications from long-term cell tracking to dynamic studies with 11C- and 15O-labelled radiotracers in rats.

Large ring diameter allows imaging of multiple mice and large animals, while the unique, Tera-Tomo™ 3D iterative reconstruction based on real-time Monte Carlo simulation ensures homogeneous image quality over the entire field of view.
Open access to the animal during PET scanning gives full control over the animal studies.
The PET system is also available in triple-modality combination with our high-end SPECT (nanoScan SPECT/CT/PET) or fully integrated with MRI (nanoScan PET/MRI).

Features & Benefits

Resolving precise details with 700 μm spatial resolution

  • Finest lutetium oxyorthosilicate (LSO) crystal needles provide precise signal localization preserving spatial information in raw data
  • Tera-Tomo™ 3D PET iterative reconstruction with real-time Monte Carlo based physical modelling unveiling the tiniest details on the image
  • Large ring diameter and statistical depth of interaction compensation offer homogeneous image quality over the entire field of view

Uncompromised applications with very low level of radioactivity

  • Thick LSO crystals for excellent sensitivity
  • Advanced corrections (random, scatter, LSO background etc.) ensuring quantification at low activity levels
  • Best minimal detectable activity on the market: 60 Bq (1.6 nCi)
  • Inherently optimized for longitudinal studies e.g. long-term cell tracking

Coping with count rate: mastering studies with high dose

  • Multichannel read-out electronics with ultra-fast data processing and advanced dead-time correction
  • Exceptional count rate performance – peak noise equivalent count rate (NECR) for mouse is 850 kcps @ 60 MBq
  • Fully quantitative at 60 MBq (1.6 mCi) and beyond
  • Suitable for dynamic imaging of large animals or for dynamic scanning of up to four mice simultaneously
  • Optimal for imaging of isotopes with short half-life (11C, 13N, 15O etc.)

Largest transaxial field of view

  • Wide bore diameter of 16 cm allowing open access to the animals
  • Large transaxial field of view of 12 cm
  • Excellent homogeneity over the entire field of view
  • Suitable for various animal models from tiny mouse to large rabbits (6.5 kg)
  • Simultaneous multiple animal imaging (up to 4 mice or 2 rats) with individual physiological monitoring function

Excellent image quality and quantitation accuracy with the Tera-Tomo™ image reconstruction

  • 3D iterative reconstruction applying deep Monte Carlo based physical modelling of particle-level interaction from positron emission to detection
  • Advanced corrections for energy, time, dead-time and random events and positron range
  • CT or MR based attenuation and scatter correction
  • Readily available acquisition and reconstruction protocols optimized for wide range of applications
  • Automated workflow with 4D multiparametric PET reconstruction for fast kinetic analysis of dynamic acquisitions

High power CT with large field-of-view and high resolution

  • Up to 80 W X-ray power enables high-performance scanning even for large or multiple animals
  • Variable magnification for high-resolution imaging with 10 μm isotropic voxel size
  • Very high throughput: fast scanning with real-time image reconstruction combined with multiple animal imaging capability
  • Iterative image reconstruction for low-noise and low-dose imaging
  • Ultra-low-dose protocol for follow-up studies with only 1 mSv whole-body dose to the animal
  • Imaging with cardiac and respiratory gating

Applications

In Vivo Cell tracking with Zr-89

Last time point of a long-term follow-up study for cell tracking. Images were taken 17 days post-injection.

  • Animal: 20 g mouse
  • Radiotracer:

30kBq (0.8μCi) 89Zr – oxine labelled cells

  • Acquisition: static PET

Short half-life isotope imaging with 11C in mouse

High count rate tolerance allows quantitative dynamic imaging of multiple animals even with short half-life radiotracers.

  • Animal: 2x 20g mice
  • Radiotracer:

5.15 MBq (139 μCi) and 5.28 MBq (142 μCi) 11C – choline per mouse

  • Acquisition: dynamic PET

Simultaneous dynamic multiple animal imaging

Simultaneous dynamic scan of 4 mice. Temperature control and physiological monitoring of all animals ensure quantitative readout of metabolic activity of organs.

  • Animal: 4x 20g mice
  • Radiotracer: 3.7 MBq (100 μCi) 18F-FDG
  • Acquisition: dynamic PET

Cardiac gated imaging

Excellent cardiac gated image quality for functional analysis of the heart.

  • Animal: 18g mouse
  • Radiotracer: 13.3 MBq (360 μCi) 18F-FDG
  • Acquisition: ECG-gated PET

Publications

Images

Specification

PET
CT
MRI
Gantry opening
16 cm
Transaxial FOV
12 cm
Axial FOV
15 cm
Animal models
Mouse, rat, marmoset, guinea pig, rabbit
Multiple animal imaging
up to 4 x 60 g mice 2 x 500 g rats
Detector crystal
LSO (1.12 x 1.12 x 13 mm)
Spatial resolution with Tera-Tomo (3D OSEM)
0.7 mm
Spatial Resolution with FBP (NEMA)
1.25 mm
Sensitivity
10.5% (250-750 keV)
Noise Equivalent Count Rate for mouse (NEMA)
1300 kcps @ 80 MBq
Noise Equivalent Count Rate for rat (NEMA)
250 kcps @ 60 MBq
X-ray power
up to 80 W
Gantry opening
16 cm
Transaxial FOV
12 cm
Axial FOV
10 cm
Animal models
mouse, rat, marmoset, guinea pig, rabbit
Multiple animal imaging
up to 4 x 60 g mice 2 x 500 g rats
Image reconstruction
modified Feldkamp-type for real-time reconstruction, iterative for low-dose and low-noise applications
Spatial resolution
30 μm at 10 μm voxel size
Low-dose protocol
down to 1 mSv for whole-body mouse
Magnet
Maintenance-free permanent magnet with 1 Tesla field strength
Magnetic fringe field
Zero (5 Gauss line is inside the cover)
Shielding
Integrated RF shielding, no need for Faraday cage
RF Coils
Volume coils: whole-body mouse, whole-body rat; Surface coils: mouse brain, rat brain
Spatial resolution
100 μm in vivo <100 µm ex vivo

Downloads

NS-PC_0923_EN web.pdf

11.60 Mb

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